Gene Annotation: Case 1
region in mouse and human two different polypeptides are synthesized
from overlapping parts of a continuous DNA sequence due to translational recoding
as a result of programmed -1 ribosomal slippage (ribosomal frameshift). In this
case, one section of the unique mRNA transcript from this region (pictured below)
corresponds to the amino acid sequence of one polypeptide, whilst an overlapping
sequence corresponds, in a different reading frame, to the amino acid sequence of
a second polypeptide. This is, of course, a common phenomenon in RNA viruses and
retrotransposons, but here we see a similar mechanism operating in eukaryote genomes.
Would you describe this case as one in which
more than one
involved in generating the final transcript/s and/or the polypeptide/s that result
from the process described?
Clearly one gene
Probably only one gene
Probably more than one gene
Clearly more than one gene
How appropriate are the following descriptions of this case? (If alphabetic letters
are used to mark a RNA segment, we are referring to the corresponding DNA sequence.)
One gene: A to C
Two genes: A + B and B + C
Are there any other specific names you would use for any of the regions of the
sequence in this case?
If the case description does not provide you with the information you need to
reply, please indicate what else you would need to know.